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Drug Interactions between methohexital and PP-Cap

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

propoxyphene methohexital

Applies to: PP-Cap (propoxyphene) and methohexital

ADJUST DOSE: Narcotic analgesics may reduce the dosage of barbiturate anesthetics needed to induce anesthesia by as much as 40%. Additionally, apnea is more common with this combination.

MANAGEMENT: Respiratory and cardiovascular status should be closely monitored, and anesthetic dosages titrated accordingly.

References

  1. DeLapa RJ "Influence of alphaprodine hydrochloride on intravenous barbiturate induction dosage." J Oral Surg 18 (1960): 163-8
  2. Dundee JW, Halliday NJ, McMurray TJ, Harper KW "Pretreatment with opioids: the effect on thiopentone induction requirements and on the onset of action of midazolam." Anaesthesia 41 (1986): 159-61
  3. Stambaugh JE, Hemphill DM, Wainer IW, Schwartz I "A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone." Lancet 1 (1977): 398-9
  4. Stambaugh JE, Wainer IW, Schwartz I "The effect of phenobarbital on the metabolism of meperidine in normal volunteers." J Clin Pharmacol 18 (1978): 482-90
View all 4 references

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Drug and food interactions

Major

propoxyphene food

Applies to: PP-Cap (propoxyphene)

GENERALLY AVOID: Alcohol may have additive CNS- and/or respiratory-depressant effects with propoxyphene. Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths, particularly in patients with a history of emotional disturbances, suicidal ideation, or alcohol and drug abuse.

MANAGEMENT: The use of alcohol during propoxyphene therapy should be avoided. Patients should be warned not to exceed the recommended dosage of propoxyphene and to avoid activities requiring mental alertness until they know how these agents affect them.

References

  1. "Product Information. Darvon (propoxyphene)." Lilly, Eli and Company PROD (2001):

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Major

methohexital food

Applies to: methohexital

GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.

MANAGEMENT: The combination of ethanol and barbiturates should be avoided.

References

  1. Gupta RC, Kofoed J "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J 94 (1966): 863-5
  2. Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med 51 (1971): 346-51
  3. Saario I, Linnoila M "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh) 38 (1976): 382-92
  4. Stead AH, Moffat AC "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol 2 (1983): 5-14
  5. Seixas FA "Drug/alcohol interactions: avert potential dangers." Geriatrics 34 (1979): 89-102
View all 5 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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