Drug Interactions between mercaptopurine and Purinethol
This report displays the potential drug interactions for the following 2 drugs:
- mercaptopurine
- Purinethol (mercaptopurine)
Interactions between your drugs
No interactions were found between mercaptopurine and Purinethol. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
mercaptopurine
A total of 280 drugs are known to interact with mercaptopurine.
- Mercaptopurine is in the drug class antimetabolites.
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Mercaptopurine is used to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Autoimmune Hepatitis (off-label)
- Crohn's Disease, Active (off-label)
- Crohn's Disease, Maintenance (off-label)
- Inflammatory Bowel Disease (off-label)
- Intestinal Arterial Insufficiency (off-label)
- Ulcerative Colitis, Maintenance (off-label)
Purinethol
A total of 280 drugs are known to interact with Purinethol.
- Purinethol is in the drug class antimetabolites.
- Purinethol is used to treat Acute Lymphoblastic Leukemia.
Drug and food interactions
mercaptopurine food
Applies to: mercaptopurine and Purinethol (mercaptopurine)
ADJUST DOSING INTERVAL: Limited data suggest that food may decrease the oral bioavailability of 6-mercaptopurine (6-MP). In one study, the pharmacokinetics of 6-MP were studied on two separate occasions in seven patients. A single dose of 6-MP was administered after an overnight fast on one occasion and 15 minutes after a standard breakfast on the other. The authors reported that peak plasma levels of 6-MP were lower and took longer to reach following administration in the fed state. In addition, plasma levels were undetectable (less than 20 ng/mL) in two patients.
MANAGEMENT: Until more information is available regarding the effect of food on 6-MP absorption, it may be advisable to take 6-MP on an empty stomach 1 hour before or 2 hours after a meal.
References
- Schmidt LE, Dalhoff K (2002) "Food-drug interactions." Drugs, 62, p. 1481-502
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Immunity modifying agents
Therapeutic duplication
The recommended maximum number of medicines in the 'immunity modifying agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'immunity modifying agents' category:
- mercaptopurine
- Purinethol (mercaptopurine)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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