Drug Interactions between Lunelle and Risperdal
This report displays the potential drug interactions for the following 2 drugs:
- Lunelle (estradiol/medroxyprogesterone)
- Risperdal (risperidone)
Interactions between your drugs
No interactions were found between Lunelle and Risperdal. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Lunelle
A total of 409 drugs are known to interact with Lunelle.
- Lunelle is in the following drug classes: contraceptives, sex hormone combinations.
- Lunelle is used to treat Birth Control.
Risperdal
A total of 668 drugs are known to interact with Risperdal.
- Risperdal is in the drug class atypical antipsychotics.
- Risperdal is used to treat the following conditions:
Drug and food interactions
risperiDONE food
Applies to: Risperdal (risperidone)
GENERALLY AVOID: Risperidone oral solution is not compatible with either tea or cola. In addition, alcohol may potentiate some of the pharmacologic effects of risperidone. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Risperidone oral solution should not be mixed with tea or cola. It may be taken with water, coffee, orange juice, or lowfat milk. Patients should also be advised to avoid consumption of alcohol.
References
- (2001) "Product Information. Risperdal (risperidone)." Janssen Pharmaceuticals
estradiol food
Applies to: Lunelle (estradiol / medroxyprogesterone)
Coadministration with grapefruit juice may increase the bioavailability of oral estrogens. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall induced by certain compounds present in grapefruits. In a small, randomized, crossover study, the administration of ethinyl estradiol with grapefruit juice (compared to herbal tea) increased peak plasma drug concentration (Cmax) by 37% and area under the concentration-time curve (AUC) by 28%. Based on these findings, grapefruit juice is unlikely to affect the overall safety profile of ethinyl estradiol. However, as with other drug interactions involving grapefruit juice, the pharmacokinetic alterations are subject to a high degree of interpatient variability. Also, the effect on other estrogens has not been studied.
References
- Weber A, Jager R, Borner A, et al. (1996) "Can grapefruit juice influence ethinyl estradiol bioavailability?" Contraception, 53, p. 41-7
- Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T (1995) "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet, 20, p. 219-24
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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