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Drug interactions between Lomotil and Viberzi

Results for the following 2 drugs:
Lomotil (atropine/diphenoxylate)
Viberzi (eluxadoline)

Interactions between your drugs

Moderate

atropine eluxadoline

Applies to: Lomotil (atropine / diphenoxylate) and Viberzi (eluxadoline)

Using eluxadoline together with atropine may increase the risk and/or severity of constipation and other gastrointestinal complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should stop taking eluxadoline and contact your doctor if you develop constipation that lasts more than 4 days. Always seek advice from a health care professional before taking any over-the-counter medications for diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

diphenoxylate eluxadoline

Applies to: Lomotil (atropine / diphenoxylate) and Viberzi (eluxadoline)

Using eluxadoline together with diphenoxylate may increase the risk and/or severity of constipation and other gastrointestinal complications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should stop taking eluxadoline and contact your doctor if you develop constipation that lasts more than 4 days. Always seek advice from a health care professional before taking any over-the-counter medications for diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

eluxadoline food

Applies to: Viberzi (eluxadoline)

Eluxadoline should be taken twice daily with food. You should avoid excessive alcohol use during treatment with eluxadoline. Consumption of more than 3 alcoholic beverages per day while taking eluxadoline may increase the risk of pancreatitis, or inflammation of the pancreas. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you experience potential symptoms of pancreatitis such as persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, especially that which is made worse after eating or radiates to the back or shoulders. Symptoms of pancreatitis usually go away when treatment with eluxadoline is stopped.

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Moderate

diphenoxylate food

Applies to: Lomotil (atropine / diphenoxylate)

Alcohol can increase the nervous system side effects of diphenoxylate such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with diphenoxylate. Do not use more than the recommended dose of diphenoxylate, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Antidiarrheals

Therapeutic duplication

The recommended maximum number of medicines in the 'antidiarrheals' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antidiarrheals' category:

  • Lomotil (atropine/diphenoxylate)
  • Viberzi (eluxadoline)

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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