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Drug interactions between levothyroxine and Xenical

Results for the following 2 drugs:
levothyroxine
Xenical (orlistat)

Interactions between your drugs

Moderate

levothyroxine ↔ orlistat

Applies to:levothyroxine and Xenical (orlistat)

Taking levothyroxine and orlistat at the same time may reduce the blood levels of levothyroxine. You should take these medications at least four hours apart. In addition, your doctor may need to monitor your thyroid function more frequently. Let your doctor know if your condition changes or if you experience symptoms like tiredness, sluggishness, muscle weakness or pain, stiffness or swelling in the joints, depression, constipation, hoarseness, unexplained weight gain, hair loss, brittle nails, pale or dry skin, cold intolerance, memory problems, confusion, or menstrual irregularities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

levothyroxine food

Applies to: levothyroxine

The timing of meals relative to your levothyroxine dose can affect absorption of the medication. Therefore, levothyroxine should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of levothyroxine may be decreased by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, calcium, and calcium fortified juices. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. When levothyroxine is given during continuous enteral nutrition (tube feedings) for more than 7 days, the tube feeding should be interrupted for at least one hour before and one hour after the dose of levothyroxine. You may need more frequent blood tests to monitor levothyroxine levels.

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Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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