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Drug Interactions between leucovorin and pafolacianine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

leucovorin pafolacianine

Applies to: leucovorin and pafolacianine

ADJUST DOSING INTERVAL: Concomitant administration of folate, folic acid, or folate-containing supplements may reduce the binding of pafolacianine to folate receptors overexpressed on ovarian cancer cells. This may lead to a reduction in the detection of malignant lesions with pafolacianine.

MANAGEMENT: Concomitant use of folate, folic acid, or folate-containing supplements with pafolacianine is not recommended. The manufacturer advises that these supplements should be discontinued 48 hours before the administration of pafolacianine.

References

  1. "Product Information. Cytalux (pafolacianine)." Grand River Aseptic Manufacturing (2021):

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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