Can you take Lemborexant with Treosulfan?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- lemborexant
- treosulfan
Drug interactions
Moderate drug interactions
Moderate:
treosulfan lemborexant
Applies to: treosulfan and lemborexant
Treosulfan may increase the blood levels and effects of lemborexant.
Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
lemborexant Food/Lifestyle
Applies to: lemborexant
Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lemborexant unless directed otherwise by your doctor.
Grapefruit juice can increase the blood levels of lemborexant. This may increase the risk of side effects such as:
- central nervous system depression
- abnormal sleep behaviors
- worsening of depression or suicidal thoughts
- changes in heartbeat
- headache
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
7 potential interactions Applies to: 6 conditions, including Depression, Seizures, Liver Disease, Alcoholism, and Renal Dysfunction.
Alcoholism
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Alcoholism.
Patients treated with lemborexant should not consume alcohol as it can increase drowsiness and also the incidence of adverse effects.
Depression
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Depression.
Worsening of depression and suicidal thoughts and actions have been reported with the use of lemborexant. Caution is advised in patients with depression. Protective measures may be required in patients with suicidal tendencies, including prescription of the lowest number of tablets at one time.
Liver Disease
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Liver Disease.
Lemborexant has not been studied in patients with severe liver dysfunction (Child-Pugh Class C). Its use is not recommended in these patients.
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Liver Disease.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Pulmonary Impairment
Moderate:
lemborexant
Lemborexant has a moderate potential interaction with Pulmonary Impairment.
Lemborexant has not been studied in patients with moderate to severe obstructive sleep apnea (OSA) or in patients with chronic obstructive pulmonary disease. Caution is advised if prescribing to patients with compromised respiratory function.
Renal Dysfunction
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Renal Dysfunction.
Treosulfan has not been studied in patients with moderate or severe liver and renal dysfunction.
Seizures
Moderate:
treosulfan
Treosulfan has a moderate potential interaction with Seizures.
There have been reports of seizures in patients following treatment with treosulfan. Patients should be monitored for signs of neurological adverse reactions, and clonazepam prophylaxis may be considered for patients at higher risk for seizures, including infants.
Report options
More resources
lemborexant
A total of 490 drugs are known to interact with lemborexant.
- Lemborexant is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Lemborexant is used to treat Insomnia.
treosulfan
A total of 547 drugs are known to interact with treosulfan.
- Treosulfan is in the drug class alkylating agents.
- Treosulfan is used to treat Stem Cell Transplant Conditioning.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.