Drug Interactions between Lanoxin and Multitrace-4 Pediatric
This report displays the potential drug interactions for the following 2 drugs:
- Lanoxin (digoxin)
- Multitrace-4 Pediatric (trace elements)
Interactions between your drugs
No interactions were found between Lanoxin and Multitrace-4 Pediatric. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Lanoxin
A total of 430 drugs are known to interact with Lanoxin.
- Lanoxin is in the following drug classes: group V antiarrhythmics, inotropic agents.
- Lanoxin is used to treat the following conditions:
Multitrace-4 Pediatric
A total of 189 drugs are known to interact with Multitrace-4 Pediatric.
- Multitrace-4 pediatric is in the drug class intravenous nutritional products.
- Multitrace-4 pediatric is used to treat Parenteral Nutrition.
Drug and food interactions
digoxin food
Applies to: Lanoxin (digoxin)
Administration of digoxin with a high-fiber meal has been shown to decrease its bioavailability by almost 20%. Fiber can sequester up to 45% of the drug when given orally. Patients should be advised to maintain a regular diet without significant fluctuation in fiber intake while digoxin is being titrated.
Grapefruit juice may modestly increase the plasma concentrations of digoxin. The mechanism is increased absorption of digoxin due to mild inhibition of intestinal P-glycoprotein by certain compounds present in grapefruits. In 12 healthy volunteers, administration of grapefruit juice with and 30 minutes before, as well as 3.5, 7.5, and 11.5 hours after a single digoxin dose (0.5 mg) increased the mean area under the plasma concentration-time curve (AUC) of digoxin by just 9% compared to administration with water. Moreover, P-glycoprotein genetic polymorphism does not appear to influence the magnitude of the effects of grapefruit juice on digoxin. Thus, the interaction is unlikely to be of clinical significance.
References
- Darcy PF (1995) "Nutrient-drug interactions." Adverse Drug React Toxicol Rev, 14, p. 233-54
- Becquemont L, Verstuyft C, Kerb R, et al. (2001) "Effect of grapefruit juice on digoxin pharmacokinetics in humans." Clin Pharmacol Ther, 70, p. 311-6
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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