Interactions between Isosorbide and Veletri
1 drug interaction and 11 additional warnings found for the following 2 drugs:
- isosorbide
- Veletri (epoprostenol)
Drug interactions
Moderate drug interactions
Moderate:
isosorbide epoprostenol
Applies to: isosorbide and Veletri (epoprostenol)
Monitor
Coadministration of medicines targeting the prostacyclin pathway (e.g., prostacyclin (PGI2), PGI2 analogs, or selective non-prostanoid prostacyclin IP receptor agonists) with diuretics, agents with hypotensive properties, or other vasodilators may potentiate the hypotensive effects of these agents. The mechanism involves the additive reduction in blood pressure due to the vasodilatory effects of PGI2, PGI2 analogs or selective non-prostanoid prostacyclin IP receptor agonists on the prostacyclin pathway.
Management
While therapies that target the prostacyclin pathway have been used in combination with diuretics, antihypertensives, or other vasodilators in the management of pulmonary arterial hypertension, caution is recommended if they must be administered concurrently. If these drugs are used together, it is generally recommended that blood pressure be measured more frequently until a stable blood pressure pattern is observed. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their doctor if they experience dizziness, lightheadedness, syncope, orthostatic hypotension, or tachycardia. Treatment guidelines should be consulted for the optimum management of pulmonary arterial hypertension.
References (7)
- Buchdahl RM, Taylor P, Warner JD (1985) "Nebulised ribavirin for adenovirus pneumonia." Lancet, 2, p. 1070-1
- (2001) "Product Information. Flolan (epoprostenol)." Glaxo Wellcome
- (2002) "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc
- (2002) "Product Information. Remodulin (treprostinil)." United Therapeutics Corporation
- (2005) "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
11 potential interactions Applies to: 10 conditions, including Heart Failure, Psychosis, Pulmonary Edema, Diabetes Mellitus, and Liver Disease.
Anuria
Major:
isosorbide
Isosorbide has a major potential interaction with Anuria.
The use of osmotic diuretics is contraindicated in patients with anuria, severe dehydration, pulmonary edema, or severe cardiac decompensation. An increase in the tonicity of the blood may occur in these patients that could exacerbate these conditions.
Bleeding Disorder
Moderate:
Veletri
The epoprostenol in Veletri has a moderate potential interaction with Bleeding Disorder.
Epoprostenol is a potent inhibitor of platelet aggregation. Therefore, expect an increased risk for hemorrhagic complications, particularly for patients with other risk factors for bleeding. Caution and close monitoring is advised.
Cerebral Thrombosis/Embolism
Moderate:
Veletri
The epoprostenol in Veletri has a moderate potential interaction with Cerebral Thrombosis/Embolism.
Epoprostenol is a potent inhibitor of platelet aggregation. Therefore, expect an increased risk for hemorrhagic complications, particularly for patients with other risk factors for bleeding. Caution and close monitoring is advised.
Dehydration
Major:
isosorbide
Isosorbide has a major potential interaction with Dehydration.
The use of osmotic diuretics is contraindicated in patients with anuria, severe dehydration, pulmonary edema, or severe cardiac decompensation. An increase in the tonicity of the blood may occur in these patients that could exacerbate these conditions.
Diabetes Mellitus
Moderate:
isosorbide
Isosorbide has a moderate potential interaction with Diabetes Mellitus.
The use of osmotic diuretics is associated with an increase in blood tonicity. Osmotic diuretics should be administered cautiously in patients with confused mental states, diabetes, congestive heart failure, severe dehydration, and cardiac, renal, or hepatic disease.
Heart Failure
Major:
isosorbide
Isosorbide has a major potential interaction with Heart Failure.
The use of osmotic diuretics is contraindicated in patients with anuria, severe dehydration, pulmonary edema, or severe cardiac decompensation. An increase in the tonicity of the blood may occur in these patients that could exacerbate these conditions.
Major:
Veletri
The epoprostenol in Veletri has a major potential interaction with Heart Failure.
The use of epoprostenol is contraindicated in patients with heart failure due to reduced severe left ventricular systolic dysfunction. A large study involving such patients was terminated after an interim analysis revealed a higher mortality in the group receiving epoprostenol plus standard therapy than in the group receiving standard therapy alone.
Liver Disease
Moderate:
isosorbide
Isosorbide has a moderate potential interaction with Liver Disease.
The use of osmotic diuretics is associated with an increase in blood tonicity. Osmotic diuretics should be administered cautiously in patients with confused mental states, diabetes, congestive heart failure, severe dehydration, and cardiac, renal, or hepatic disease.
Psychosis
Moderate:
isosorbide
Isosorbide has a moderate potential interaction with Psychosis.
The use of osmotic diuretics is associated with an increase in blood tonicity. Osmotic diuretics should be administered cautiously in patients with confused mental states, diabetes, congestive heart failure, severe dehydration, and cardiac, renal, or hepatic disease.
Pulmonary Edema
Major:
isosorbide
Isosorbide has a major potential interaction with Pulmonary Edema.
The use of osmotic diuretics is contraindicated in patients with anuria, severe dehydration, pulmonary edema, or severe cardiac decompensation. An increase in the tonicity of the blood may occur in these patients that could exacerbate these conditions.
Renal Dysfunction
Moderate:
isosorbide
Isosorbide has a moderate potential interaction with Renal Dysfunction.
The use of osmotic diuretics is associated with an increase in blood tonicity. Osmotic diuretics should be administered cautiously in patients with confused mental states, diabetes, congestive heart failure, severe dehydration, and cardiac, renal, or hepatic disease.
Report options
More resources
isosorbide
A total of 126 drugs are known to interact with isosorbide.
- Isosorbide is in the drug class miscellaneous uncategorized agents.
Veletri
A total of 311 drugs are known to interact with Veletri.
- Veletri is in the drug class agents for pulmonary hypertension.
- Veletri is used to treat Pulmonary Arterial Hypertension.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.