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Drug Interactions between irinotecan and succinylcholine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

succinylcholine irinotecan

Applies to: succinylcholine and irinotecan

Theoretically, irinotecan may augment the pharmacologic effect of depolarizing neuromuscular blocking agents due to its anticholinesterase activity. Depolarizing neuromuscular blocking agents are rapidly hydrolyzed by plasma cholinesterase, thus inhibitors of cholinesterase may reduce their clearance from plasma and prolong their effect. However, the interaction has not been studied or reported in a clinical setting.

References (2)
  1. (2001) "Product Information. Anectine (succinylcholine)." Glaxo Wellcome
  2. (2001) "Product Information. Camptosar (irinotecan)." Pharmacia and Upjohn

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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