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Drug Interactions between Intelence and Solurex LA

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dexAMETHasone etravirine

Applies to: Solurex LA (dexamethasone) and Intelence (etravirine)

MONITOR: Coadministration of etravirine with a drug that is both a substrate as well as inducer of CYP450 3A4 may result in decreased plasma concentrations of both drugs. Etravirine itself is also a substrate and inducer of CYP450 3A4. Theoretically, metabolism of etravirine and the coadministered drug may be mutually induced when used in combination.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if etravirine is prescribed in combination with a drug that is an inducer of CYP450 3A4. Close clinical and laboratory monitoring of antiretroviral response is recommended. In addition, dosage adjustments may be required for the coadministered drug if it is also a substrate of CYP450 3A4.

References

  1. "Product Information. Intelence (etravirine)." Ortho Biotech Inc (2008):

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Drug and food interactions

Moderate

etravirine food

Applies to: Intelence (etravirine)

ADJUST DOSING INTERVAL: Coadministration with food increases the oral bioavailability of etravirine. The mechanism is unknown. Compared to administration following a meal, the systemic exposure (AUC) to etravirine was decreased by about 50% when the drug was administered under fasting conditions. The types of meal studied (ranging from 345 kilocalories containing 17 grams fat to 1160 kilocalories containing 70 grams fat) did not appear to make a difference with respect to impact on etravirine bioavailability.

MANAGEMENT: Etravirine should always be administered following a meal.

References

  1. "Product Information. Intelence (etravirine)." Ortho Biotech Inc (2008):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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