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Drug Interactions between indomethacin and Probenecid and Colchicine

This report displays the potential drug interactions for the following 2 drugs:

  • indomethacin
  • Probenecid and Colchicine (colchicine/probenecid)

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Interactions between your drugs

Moderate

probenecid indomethacin

Applies to: Probenecid and Colchicine (colchicine / probenecid) and indomethacin

Using indomethacin together with probenecid may increase the effects of indomethacin. Contact your doctor if you experience nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, ringing in the ears, shallow breathing, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

colchicine food

Applies to: Probenecid and Colchicine (colchicine / probenecid)

Drinking large amounts of grapefruit juice can increase your blood levels of colchicine to dangerous levels. You should avoid the consumption of grapefruit or grapefruit juice during treatment with colchicine. Let your doctor know if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet, as these may be early symptoms of colchicine toxicity.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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