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Drug Interactions between i3odine Max and Mono-Gesic

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium iodide I-131 salsalate

Applies to: i3odine Max (sodium iodide-i-131) and Mono-Gesic (salsalate)

ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.

MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.

References

  1. "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare (2022):

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Drug and food interactions

Moderate

sodium iodide I-131 food

Applies to: i3odine Max (sodium iodide-i-131)

MONITOR: Excessive intake of dietary iodine (e.g., iodised salt) may interfere with adequate uptake of radioiodide by the thyroid .

MANAGEMENT: A diet low in iodine is recommended before initiating therapy with sodium iodide I-131 or I-123.

References

  1. Cerner Multum, Inc. "Australian Product Information." O 0

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Moderate

salsalate food

Applies to: Mono-Gesic (salsalate)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):

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Moderate

sodium iodide I-131 food

Applies to: i3odine Max (sodium iodide-i-131)

ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.

MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.

References

  1. "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare (2022):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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