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Drug Interactions between hydrocortisone and Suboxone

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

hydrocortisone naloxone

Applies to: hydrocortisone and Suboxone (buprenorphine / naloxone)

A possible synergy was noted in a patient given a normal dose of naloxone followed by a 200 mg dose of hydrocortisone. In this case, naloxone was given for obtundation with minimal effect. The hydrocortisone was given in the same intravenous line approximately two minutes after the naloxone. Immediately after the hydrocortisone was given, the patient became alert. It is not known whether this effect was truly the result of a drug interaction.

References (1)
  1. Hensher R (1983) "A possible interaction between intravenous naloxone and hydrocortisone." Br J Clin Pract, 37, p. 399-400

Drug and food interactions

Major

buprenorphine food

Applies to: Suboxone (buprenorphine / naloxone)

GENERALLY AVOID: Alcohol may potentiate the central nervous system (CNS) depressant effects of opioid analgesics including buprenorphine. Concomitant use may result in additive CNS depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, hypotension, respiratory depression, profound sedation, coma, or even death may occur.

MANAGEMENT: Patients taking buprenorphine should not consume alcohol or use medications that contain alcohol on days of buprenorphine dosing. In general, potent narcotics such as buprenorphine should not be combined with alcohol.

References (4)
  1. (2023) "Product Information. Sublocade (buprenorphine)." Indivior Inc., SUPPL-28
  2. (2023) "Product Information. Probuphine (buprenorphine)." Titan Pharmaceuticals Inc, SUPPL-14
  3. (2023) "Product Information. Buprenorphine (buprenorphine)." G.L. Pharma UK Ltd
  4. (2023) "Product Information. Temgesic (buprenorphine)." Reckitt Benckiser Pty Ltd

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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