Drug Interactions between hydrochlorothiazide / metoprolol and olodaterol / tiotropium

Using metoprolol and hydroCHLOROthiazide together may lower your blood pressure and slow your heart rate. This can cause dizziness, or feeling like you might pass out, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using metoprolol together with olodaterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, metoprolol can sometimes cause narrowing of the airways, which may worsen your breathing problems or trigger severe asthmatic attacks. You may not be able to use metoprolol if you have frequent asthma attacks or severe asthma or COPD (chronic obstructive pulmonary disease), or you may need a dose adjustment and more frequent monitoring of your lung function to safely use both medications. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. Let your doctor know if you experience wheezing, shortness of breath, chest tightness, or other breathing difficulties during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Using hydroCHLOROthiazide together with olodaterol may increase the risk of developing hypokalemia, or low blood potassium. In severe cases, hypokalemia can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. The risk may exist even when olodaterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. Let your doctor know if you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness, tingling, rapid heartbeat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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