Can you take Human papillomavirus vaccine with Tildrakizumab?
1 drug interaction and 11 additional warnings found for the following 2 drugs:
- human papillomavirus vaccine
- tildrakizumab
Drug interactions
Moderate drug interactions
Moderate:
human papillomavirus vaccine tildrakizumab
Applies to: human papillomavirus vaccine and tildrakizumab
If you are currently being treated or have recently been treated with tildrakizumab, you should let your doctor know before receiving human papillomavirus vaccine. Depending on the dose and length of time you have been on tildrakizumab, you may have a reduced response to the vaccine. In some situations, your doctor may want to delay vaccination to give your body time to recover from the effects of tildrakizumab therapy. If you have recently been vaccinated with human papillomavirus vaccine, your doctor may choose to postpone treatment with tildrakizumab for a couple of weeks or more. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
11 potential interactions Applies to: 10 conditions, including Hypotension, Fever, Syncope, Infection, and Dehydration.
Dehydration
Moderate:
human papillomavirus vaccine
Human papillomavirus vaccine has a moderate potential interaction with Dehydration.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
Fever
Major:
human papillomavirus vaccine
Human papillomavirus vaccine has a major potential interaction with Fever.
Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.
History, Tuberculosis
Major:
tildrakizumab
Tildrakizumab has a major potential interaction with History, Tuberculosis.
Do not administer tildrakizumab to patients with active TB infection. It is recommended to assess patients for tuberculosis (TB) infection before starting treatment with this agent. Consider anti-TB therapy prior to initiation of tildrakizumab in patients with latent TB, a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after treatment with tildrakizumab.
Hypotension
Moderate:
human papillomavirus vaccine
Human papillomavirus vaccine has a moderate potential interaction with Hypotension.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
Immunodeficiency
Moderate:
human papillomavirus vaccine
Human papillomavirus vaccine has a moderate potential interaction with Immunodeficiency.
The expected serum antibody responses may not be obtained when vaccines and/or toxoids are administered to patients with primary or acquired immunodeficiency, including those with severe combined immunodeficiency, hypogammaglobulinemia or agammaglobulinemia, HIV infection, altered immune states (due to diseases such as leukemia, lymphoma, or generalized malignancy), or immunosuppression due to drug or other treatments (e.g., corticosteroids, alkylating agents, antimetabolites, or radiation).
Infection
Major:
human papillomavirus vaccine
Human papillomavirus vaccine has a major potential interaction with Infection.
Ideally, vaccination should occur when an individual is healthy, thus minimizing the risk of an adverse host reaction and/or vaccine failure. However, a current or recent infection does not necessarily preclude the use of vaccines, depending on the severity of the patient's symptoms and their etiology. Superficial infections and minor acute illnesses such as a mild upper respiratory infection with or without low-grade fever do not contraindicate immunization, particularly if prompt administration of a vaccine is deemed necessary or beneficial. In fact, when vaccines are administered during the course of a minor illness, the risk of adverse events is not increased, and serum antibody response is not often diminished. On the other hand, if fever or symptoms suggest a moderate or severe illness, it is usually appropriate to withhold vaccination until the patient has recovered. In addition to the potential risks already mentioned, evolving signs and symptoms of the illness can sometimes confound the diagnosis of a vaccine reaction if it develops. In the presence of any infection, the decision to administer or withhold/defer immunization should take into consideration the benefits versus the risks to an individual patient.
Moderate:
tildrakizumab
Tildrakizumab has a moderate potential interaction with Infection.
The use of tildrakizumab may increase the risk of infection. Treatment with tildrakizumab should not be started in patients with active infection until the infection resolves or is adequately treated. Consider the risks and benefits prior to using this agent in patients with chronic infection or a history of recurrent infection. It is recommended to monitor the patient closely and consider discontinuation of tildrakizumab if a patient develops a clinically important or serious infection or is not responding to standard therapy.
Syncope
Moderate:
human papillomavirus vaccine
Human papillomavirus vaccine has a moderate potential interaction with Syncope.
The administration of human papillomavirus vaccine has been associated with syncope, sometimes resulting in falling with injury. The syncope sometimes is associated with tonic-clonic movements and other seizure-like activity. Caution is recommended when administering the vaccine to individuals susceptible to syncope. Observation for 15 minutes is recommended after its administration.
Tuberculosis, Active
Major:
tildrakizumab
Tildrakizumab has a major potential interaction with Tuberculosis, Active.
Do not administer tildrakizumab to patients with active TB infection. It is recommended to assess patients for tuberculosis (TB) infection before starting treatment with this agent. Consider anti-TB therapy prior to initiation of tildrakizumab in patients with latent TB, a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after treatment with tildrakizumab.
Tuberculosis, Latent
Major:
tildrakizumab
Tildrakizumab has a major potential interaction with Tuberculosis, Latent.
Do not administer tildrakizumab to patients with active TB infection. It is recommended to assess patients for tuberculosis (TB) infection before starting treatment with this agent. Consider anti-TB therapy prior to initiation of tildrakizumab in patients with latent TB, a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients for signs and symptoms of active TB during and after treatment with tildrakizumab.
Vaccination
Moderate:
tildrakizumab
Tildrakizumab has a moderate potential interaction with Vaccination.
It is recommended to avoid the use of live vaccines in patients treated with tildrakizumab. Before starting therapy with tildrakizumab, consider completion of all age appropriate immunizations according to current immunization guidelines. Care should be exercised as no data are available on the response to live or inactive vaccines.
More resources
human papillomavirus vaccine
A total of 340 drugs are known to interact with human papillomavirus vaccine.
- Human papillomavirus vaccine is in the drug class viral vaccines.
- Human papillomavirus vaccine is used to treat Human Papillomavirus Prophylaxis.
tildrakizumab
A total of 205 drugs are known to interact with tildrakizumab.
- Tildrakizumab is in the drug class interleukin inhibitors.
- Tildrakizumab is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.