Can you take Herpetrol with Letrozole?
1 drug interaction and 3 additional warnings found for the following 2 drugs:
- Herpetrol (benzalkonium chloride/menthol topical)
- letrozole
Drug interactions
Minor drug interactions
Minor:
menthol topical letrozole
Applies to: Herpetrol (benzalkonium chloride / menthol topical) and letrozole
Coadministration with orally administered menthol may decrease plasma concentrations of drugs that are substrates of the CYP450 3A4 and/or CYP450 2C9 isoenzymes. The proposed mechanism is increased clearance due to menthol-mediated induction of CYP450 3A4 and CYP450 2C9. In vivo data suggests that concomitant administration of oral menthol reduced the systemic exposure (AUC) of triazolam (a CYP450 3A4 substrate) by 40%, and phenytoin (a CYP450 2C9 substrate) by 20%. Until further data are available, no specific precautions are recommended.
The information above is from our professional interaction data. Consumer information is not available for this interaction.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
3 potential interactions Applies to: 3 conditions, including High Cholesterol, Osteoporosis, and Liver Disease.
High Cholesterol
Moderate:
letrozole
Letrozole has a moderate potential interaction with High Cholesterol.
In an adjuvant clinical trial hypercholesterolemia was reported in 52.3% of letrozole patients and 28.6% of tamoxifen patients. CTC grade 3-4 hypercholesterolemia was reported in 0.4% of letrozole patients and 0.1% of tamoxifen patients. Also in the adjuvant setting, an increase of >=1.5 X ULN in total cholesterol (generally non-fasting) was observed in patients on monotherapy who had baseline total serum cholesterol within the normal range (i.e., <=1.5 X ULN) in 151/1843 (8.2%) on letrozole vs 57/1840 (3.2%). Caution is recommended when prescribing letrozole to these patients. Consideration should be given to monitoring serum cholesterol.
Liver Disease
Major:
letrozole
Letrozole has a major potential interaction with Liver Disease.
Letrozole is extensively metabolized by the liver. The pharmacokinetic disposition of letrozole has not been assessed in patients with severe hepatic impairment. No dosage modification is recommended for patients with mild to moderate hepatic impairment, however, therapy with letrozole should be administered cautiously to patients with severe hepatic impairment.
Osteoporosis
Moderate:
letrozole
Letrozole has a moderate potential interaction with Osteoporosis.
Use of letrozole tablets may cause decreases in bone mineral density (BMD). Caution should exercise when prescribing this agent to patients with a risk of fractures, such as the elderly and patients with osteoporosis. Consider bone mineral density monitoring in patients treated with letrozole.
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More resources
Herpetrol
A total of 368 drugs are known to interact with Herpetrol.
- Herpetrol is in the drug class antiseptic and germicides.
- Herpetrol is used to treat Herpes Simplex (HSV).
letrozole
A total of 129 drugs are known to interact with letrozole.
- Letrozole is in the following drug classes: aromatase inhibitors, hormones/antineoplastics.
- Letrozole is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.