Can you take Halothane with Panobinostat?

Panobinostat has a moderate potential interaction with Anemia.

Panobinostat causes myelosuppression. Cases of severe thrombocytopenia, neutropenia and anemia have been reported with the use of panobinostat. It is recommended to obtain a baseline CBC and monitor the CBC frequently as clinically indicated. Dose modifications are recommended for myelosuppression.

Panobinostat has a major potential interaction with Arrhythmia.

Severe and fatal cardiac ischemic events, as well as severe arrhythmias, and electrocardiogram (ECG) changes have occurred in patients receiving panobinostat. Panobinostat may prolong cardiac ventricular repolarization (QT interval). Do not initiate treatment with panobinostat in patients with a QTcF >450 msec or clinically significant baseline ST-segment or T-wave abnormalities. If during treatment, the QTcF increases to >=480 msec, interrupt treatment. Arrhythmias may be exacerbated by electrolyte abnormalities. It is recommended to obtain ECG at baseline and periodically during treatment as clinically indicated. Monitor patient hydration status and electrolyte blood levels, including potassium, magnesium and phosphate, at baseline and frequently as clinically indicated during therapy and correct to prevent dehydration and electrolyte disturbances. If QT prolongation does not resolve, permanently discontinue treatment with panobinostat.

Halothane has a moderate potential interaction with Arrhythmia.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Panobinostat has a moderate potential interaction with Bone Marrow Depression/Low Blood Counts.

Panobinostat causes myelosuppression. Cases of severe thrombocytopenia, neutropenia and anemia have been reported with the use of panobinostat. It is recommended to obtain a baseline CBC and monitor the CBC frequently as clinically indicated. Dose modifications are recommended for myelosuppression.

Halothane has a moderate potential interaction with Cerebral Vascular Disorder.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Panobinostat has a major potential interaction with Electrolyte Abnormalities.

Severe and fatal cardiac ischemic events, as well as severe arrhythmias, and electrocardiogram (ECG) changes have occurred in patients receiving panobinostat. Panobinostat may prolong cardiac ventricular repolarization (QT interval). Do not initiate treatment with panobinostat in patients with a QTcF >450 msec or clinically significant baseline ST-segment or T-wave abnormalities. If during treatment, the QTcF increases to >=480 msec, interrupt treatment. Arrhythmias may be exacerbated by electrolyte abnormalities. It is recommended to obtain ECG at baseline and periodically during treatment as clinically indicated. Monitor patient hydration status and electrolyte blood levels, including potassium, magnesium and phosphate, at baseline and frequently as clinically indicated during therapy and correct to prevent dehydration and electrolyte disturbances. If QT prolongation does not resolve, permanently discontinue treatment with panobinostat.

Halothane has a moderate potential interaction with Heart Block.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Halothane has a moderate potential interaction with Hypotension.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Panobinostat has a moderate potential interaction with Infection.

Localized and systemic infections, including pneumonia, bacterial infections, invasive fungal infections, and viral infections have been reported in patients taking panobinostat. It is recommended to monitor patients for signs and symptoms of infections during treatment; if a diagnosis of infection is made, institute appropriate anti-infective treatment promptly and consider interruption or discontinuation of therapy. Care should be exercised when prescribing this agent to patients at risk.

Panobinostat has a major potential interaction with Ischemic Heart Disease.

Severe and fatal cardiac ischemic events, as well as severe arrhythmias, and electrocardiogram (ECG) changes have occurred in patients receiving panobinostat. Panobinostat may prolong cardiac ventricular repolarization (QT interval). Do not initiate treatment with panobinostat in patients with a QTcF >450 msec or clinically significant baseline ST-segment or T-wave abnormalities. If during treatment, the QTcF increases to >=480 msec, interrupt treatment. Arrhythmias may be exacerbated by electrolyte abnormalities. It is recommended to obtain ECG at baseline and periodically during treatment as clinically indicated. Monitor patient hydration status and electrolyte blood levels, including potassium, magnesium and phosphate, at baseline and frequently as clinically indicated during therapy and correct to prevent dehydration and electrolyte disturbances. If QT prolongation does not resolve, permanently discontinue treatment with panobinostat.

Halothane has a moderate potential interaction with Ischemic Heart Disease.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Panobinostat has a moderate potential interaction with Liver Disease.

Hepatic impairment can increase panobinostat exposure. It is recommended to reduce the starting dose of panobinostat in patients with mild or moderate hepatic impairment. Avoid the use of panobinostat in patients with severe hepatic impairment. Liver function should be monitored prior to treatment and regularly during treatment. If abnormal liver function tests are observed dose adjustments might be considered and the patient should be followed until values return to normal or to pretreatment levels.

Halothane has a moderate potential interaction with Pseudotumor Cerebri.

Inhalation anesthetics causes hypotension, frequently decreases pulse rate and induces supraventricular arrhythmias, and increase cerebral spinal fluid. Ventricular arrhythmia has occurred during administration of halothane due to sensitization of myocardial conduction tissue to epinephrine and norepinephrine. Therapy with inhalation anesthetics should be administered cautiously in patients with cardiovascular disorders including hemodynamic impairment or conduction disorders, significantly increased intracranial pressure, or impaired cerebral circulation.

Panobinostat has a moderate potential interaction with Renal Dysfunction.

Mild renal impairment to severe renal impairment did not impact the plasma exposure of panobinostat. The use of panobinostat has not been studied in patients with end stage renal disease or patients on dialysis. Care should be exercised when using panobinostat in these patients as the dialyzability of panobinostat is unknown.