Can you take Glycerol phenylbutyrate with Scot-Tussin DM Cough Chasers?
1 drug interaction and 5 additional warnings found for the following 2 drugs:
- glycerol phenylbutyrate
- Scot-Tussin DM Cough Chasers (dextromethorphan)
Drug interactions
Moderate drug interactions
Moderate:
dextromethorphan glycerol phenylbutyrate
Applies to: Scot-Tussin DM Cough Chasers (dextromethorphan) and glycerol phenylbutyrate
Glycerol phenylbutyrate may increase the blood levels and effects of dextromethorphan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as difficulty breathing, dizziness, drowsiness, difficulty sleeping, or diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
dextromethorphan Food/Lifestyle
Applies to: Scot-Tussin DM Cough Chasers (dextromethorphan)
Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
4 potential interactions Applies to: 4 conditions, including Peripheral Neuropathy, Liver Disease, Malabsorption Syndrome, and Renal Dysfunction.
Liver Disease
Moderate:
glycerol phenylbutyrate
Glycerol phenylbutyrate has a moderate potential interaction with Liver Disease.
Patients with hepatic impairment may have higher plasma phenylacetate (PAA) and phenylacetate to phenylacetylglutamine (PAGN) ratio due to a reduced conversion capability of PAA to PAGN in the liver. Patients with moderate to severe hepatic impairment may require lower dosages of glycerol phenylbutyrate than normal to control the patient's ammonia levels. Caution is recommended in patients with hepatic impairment as no studies have been conducted.
Malabsorption Syndrome
Moderate:
glycerol phenylbutyrate
Glycerol phenylbutyrate has a moderate potential interaction with Malabsorption Syndrome.
Pancreatic enzymes hydrolyze glycerol phenylbutyrate in the small intestine. Intestinal disease resulting in fat malabsorption may result in reduced digestion of glycerol phenylbutyrate. It is recommended to monitor the ammonia levels closely in patients with pancreatic insufficiency or intestinal malabsorption.
Peripheral Neuropathy
Moderate:
glycerol phenylbutyrate
Glycerol phenylbutyrate has a moderate potential interaction with Peripheral Neuropathy.
The major metabolite of glycerol phenylbutyrate, PAA, is associated with neurotoxicity. Cases of exacerbation of preexisting neuropathy have been documented in patients using this agent. It is recommended to exercise caution when using glycerol phenylbutyrate in patients with neuropathy.
Renal Dysfunction
Moderate:
glycerol phenylbutyrate
Glycerol phenylbutyrate has a moderate potential interaction with Renal Dysfunction.
The efficacy and safety of glycerol phenylbutyrate in patients with renal impairment are unknown. It is recommended to monitor ammonia levels closely when using this agent in patients with impaired renal function.
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glycerol phenylbutyrate
A total of 296 drugs are known to interact with glycerol phenylbutyrate.
- Glycerol phenylbutyrate is in the drug class urea cycle disorder agents.
- Glycerol phenylbutyrate is used to treat Urea Cycle Disorders.
Scot-Tussin DM Cough Chasers
A total of 375 drugs are known to interact with Scot-Tussin DM Cough Chasers.
- Scot-tussin dm cough chasers is in the drug class antitussives.
- Scot-tussin dm cough chasers is used to treat Cough.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.