Can you take Givosiran with Naropin Polyamp?
1 drug interaction and 2 additional warnings found for the following 2 drugs:
- givosiran
- Naropin Polyamp (ropivacaine)
Drug interactions
Moderate drug interactions
Moderate:
ROPivacaine givosiran
Applies to: Naropin Polyamp (ropivacaine) and givosiran
Givosiran may increase the blood levels and effects of ROPivacaine.
You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Liver Disease and Renal Dysfunction.
Liver Disease
Moderate:
givosiran
Givosiran has a moderate potential interaction with Liver Disease.
The effect of end-stage renal disease (eGFR <15 mL/min/1.73m2), and moderate to severe hepatic impairment on givosiran pharmacokinetics is unknown. Additionally, hepatic and renal toxicity was observed in up to 15% of patients treated with givosiran in clinical trials. Caution and regular monitoring is advised when using givosiran in patients with hepatic or renal impairment.
Renal Dysfunction
Moderate:
givosiran
Givosiran has a moderate potential interaction with Renal Dysfunction.
The effect of end-stage renal disease (eGFR <15 mL/min/1.73m2), and moderate to severe hepatic impairment on givosiran pharmacokinetics is unknown. Additionally, hepatic and renal toxicity was observed in up to 15% of patients treated with givosiran in clinical trials. Caution and regular monitoring is advised when using givosiran in patients with hepatic or renal impairment.
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More resources
givosiran
A total of 244 drugs are known to interact with givosiran.
- Givosiran is in the drug class miscellaneous metabolic agents.
- Givosiran is used to treat Porphyria.
Naropin Polyamp
A total of 255 drugs are known to interact with Naropin Polyamp.
- Naropin polyamp is in the drug class local injectable anesthetics.
- Naropin polyamp is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.