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Drug Interactions between Galafold and Thrombate III

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

No interactions were found between Galafold and Thrombate III. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Galafold

A total of 1 drugs are known to interact with Galafold.

Thrombate III

A total of 128 drugs are known to interact with Thrombate III.

Drug and food/lifestyle interactions

Moderate

migALAstat food/lifestyle

Applies to: Galafold (migalastat)

ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of migalastat. When migalastat was administered one hour before a high-fat (850 calories; 56% from fat) or light meal (507 calories; 30% from fat), or one hour after a light meal, mean migalastat peak plasma concentration (Cmax) decreased by 15% to 39% and systemic exposure (AUC) decreased by 37% to 42% compared to administration in the fasting state.

MANAGEMENT: Migalastat should be taken on an empty stomach. Patients should avoid eating for at least 2 hours before and 2 hours after taking migalastat to give a minimum 4 hours fast. Clear liquids can be consumed during this 4-hour period.

References (2)
  1. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  2. (2018) "Product Information. Galafold (migalastat)." Amicus Therapeutics U.S., Inc.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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