Can you take Freeze It with Ivacaftor?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- Freeze It (camphor/menthol topical)
- ivacaftor
Drug interactions
Minor drug interactions
Minor:
menthol topical ivacaftor
Applies to: Freeze It (camphor / menthol topical) and ivacaftor
Information for this minor interaction is available on the professional version.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
ivacaftor Food/Lifestyle
Applies to: ivacaftor
Ivacaftor should be taken with fat-containing foods such as eggs, avocados, nuts, meat, butter, peanut butter, cheese pizza, and whole-milk dairy products to help with its absorption. Do not consume grapefruit juice or any food that contains grapefruit or Seville oranges during treatment with ivacaftor unless directed otherwise by your doctor. Grapefruit juice can significantly increase the blood levels of ivacaftor. This may increase the risk and/or severity of serious side effects such as liver damage. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
7 potential interactions Applies to: 7 conditions, including High Blood Pressure, Cataract, Liver Disease, Organ Transplant, and Renal Dysfunction.
Cataract
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with Cataract.
Cases of non-congenital lens opacities or cataracts have been reported in pediatric patients treated with products containing ivacaftor. Although other risk factors could be present in some cases (e.g., corticosteroid use or exposure to radiation), a possible risk attributable to this medication cannot be excluded. Baseline and ophthalmological examinations are recommended in pediatric patients initiating treatment
High Blood Pressure
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with High Blood Pressure.
The use of products containing ivacaftor is associated with an increase in blood pressure. Close monitoring of blood pressure is recommended periodically in all patients, in particular in hypertensive patients.
History, Radiation Therapy
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with History, Radiation Therapy.
Cases of non-congenital lens opacities or cataracts have been reported in pediatric patients treated with products containing ivacaftor. Although other risk factors could be present in some cases (e.g., corticosteroid use or exposure to radiation), a possible risk attributable to this medication cannot be excluded. Baseline and ophthalmological examinations are recommended in pediatric patients initiating treatment
Liver Disease
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with Liver Disease.
There are no data on the use of ivacaftor in patients with severe liver dysfunction. Ivacaftor should not be used in patients less than 6 months of age with any level of hepatic impairment. Caution is recommended if using products containing ivacaftor in cystic fibrosis (CF) patients with advanced liver disease. Use of ivacaftor in these patients has been associated with worsening of liver function, including hepatic encephalopathy. In CF patients with pre-existing cirrhosis with portal hypertension, liver function decompensation, including liver failure leading to death, has been reported. Closely monitor patients as recommended by the manufacturer after initiating treatment, especially in those with liver disease or a history of transaminase/bilirubin elevations.
Organ Transplant
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with Organ Transplant.
The use of products containing ivacaftor has not been studied in patients with cystic fibrosis who have undergone organ transplantation. Use in transplanted patients is not recommended due to potential drug-drug interactions with immunosuppressants.
Pulmonary Impairment
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with Pulmonary Impairment.
The use of products containing ivacaftor is associated with respiratory events (e.g., chest discomfort, dyspnea, and respiration abnormal). Close monitoring is recommended in patients with advanced lung disease (percent predicted FEV1 less than 40).
Renal Dysfunction
Moderate:
ivacaftor
Ivacaftor has a moderate potential interaction with Renal Dysfunction.
Ivacaftor has not been studied in patients with renal impairment. No dose adjustment is necessary for patients with mild or moderate renal impairment, however, caution is recommended in patients with severe renal impairment or end-stage renal disease.
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Freeze It
A total of 364 drugs are known to interact with Freeze It.
- Freeze it is in the drug class topical rubefacient.
- Freeze it is used to treat the following conditions:
ivacaftor
A total of 468 drugs are known to interact with ivacaftor.
- Ivacaftor is in the drug class CFTR potentiators.
- Ivacaftor is used to treat Cystic Fibrosis.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.