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Drug Interactions between foscarnet and pentamidine

This report displays the potential drug interactions for the following 2 drugs:

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Major

pentamidine foscarnet

Applies to: pentamidine and foscarnet

MONITOR CLOSELY: Coadministration of foscarnet and parenteral pentamidine may cause severe hypocalcemia. Renal impairment and symptomatic hypocalcemia (Trousseau's and Chvostek's signs) have been observed during concomitant therapy, and fatalities have been reported rarely in postmarketing surveillance. An interaction is suspected based on presumed additive effects on serum calcium. In addition, both drugs may have additive nephrotoxic effects.

MANAGEMENT: Close monitoring is recommended during concomitant use of foscarnet and parenteral pentamidine. Serum creatinine and electrolyte levels should be assessed prior to initiating therapy and frequently during therapy. Patients should be advised to promptly notify their physician if they experience potential symptoms of hypocalcemia such as perioral tingling, numbness in extremities, and paresthesias.

References

  1. (1991) "Foscarnet: a review." Drugs, 41, p. 106-29
  2. (2001) "Product Information. Foscavir (foscarnet)." Astra-Zeneca Pharmaceuticals
  3. Youle M, Clarbour J, Gazzard B, Chanas A (1988) "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet, 1, p. 1455-6

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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