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Drug Interactions between Forane and Harmonyl

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

isoflurane deserpidine

Applies to: Forane (isoflurane) and Harmonyl (deserpidine)

MONITOR: Rauwolfia alkaloids may accentuate the hypotensive effects of general anesthetics by depleting catecholamine neurotransmitters. Data are conflicting and are available for rauwolfia and reserpine only.

MANAGEMENT: Patients should be closely monitored. If profound hypotension occurs, a direct-acting sympathomimetic agent, such as dobutamine or epinephrine, may be required.

References

  1. Ziegler CH, Lovette JB (1961) "Operative complications after therapy with reserpine and reserpine compounds." JAMA, 176, p. 114-7
  2. Jahr JS, Weber S (1991) "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand, 35, p. 788-9

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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