Can you take Flibanserin with Opicapone?
1 drug interaction and 13 additional warnings found for the following 2 drugs:
- flibanserin
- opicapone
Drug interactions
Moderate drug interactions
Moderate:
flibanserin opicapone
Applies to: flibanserin and opicapone
Using flibanserin together with opicapone may increase side effects such as:
- dizziness
- drowsiness
- fatigue
- difficulty concentrating
You should avoid the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery for at least 6 hours after taking flibanserin and until you know how the medications affect you.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
flibanserin Food/Lifestyle
Applies to: flibanserin
Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to:
- dizziness
- lightheadedness
- fainting
- accidental injury
What to do: Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime.
Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment.
Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate food/lifestyle interactions
Moderate:
opicapone Food/Lifestyle
Applies to: opicapone
Food may delay and reduce the absorption of opicapone, which may lead to lower blood levels of the medication and possibly reduced effectiveness.
You should take opicapone once daily at bedtime. Do not eat food for at least 1 hour before and at least 1 hour after taking opicapone.
Talk to your doctor or pharmacist if you have any questions or concerns.
Disease interactions
11 potential interactions Applies to: 9 conditions, including Hypotension, Psychosis, Lactose Intolerance, Syncope, and Liver Disease.
Adrenal Tumor
Major:
opicapone
Opicapone has a major potential interaction with Adrenal Tumor.
The use of opicapone is contraindicated in patients with pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms.
Alcoholism
Major:
flibanserin
Flibanserin has a major potential interaction with Alcoholism.
The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.
Hypotension
Major:
flibanserin
Flibanserin has a major potential interaction with Hypotension.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Moderate:
opicapone
Opicapone has a moderate potential interaction with Hypotension.
Opicapone may cause orthostatic blood pressure changes including fainting and dizziness and patients should be advised to avoid standing rapidly after sitting or lying down. Caution is advised in patients with hypotension.
Lactose Intolerance
Moderate:
opicapone
Opicapone has a moderate potential interaction with Lactose Intolerance.
Opicapone formulations contain lactose. Caution is advised if used in patients with lactose intolerance.
Liver Disease
Major:
flibanserin
Flibanserin has a major potential interaction with Liver Disease.
Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.
Moderate:
opicapone
Opicapone has a moderate potential interaction with Liver Disease.
The mean overall plasma exposure (AUC) of opicapone increased by 84% in patients with moderate (Child-Pugh Class B) liver dysfunction. A dosage adjustment is required on these patients. The pharmacokinetics of this drug have not been studied in patients with severe liver dysfunction (Child-Pugh: C). Caution is advised.
Pheochromocytoma
Major:
opicapone
Opicapone has a major potential interaction with Pheochromocytoma.
The use of opicapone is contraindicated in patients with pheochromocytoma, paraganglioma, or other catecholamine secreting neoplasms.
Psychosis
Major:
opicapone
Opicapone has a major potential interaction with Psychosis.
Opicapone may cause impulse control disorders including pathological gambling, increased libido, hypersexuality, compulsive spending or buying, binge eating, and compulsive eating. Patients with a major psychotic disorder should ordinarily not be treated with this drug because of the risk of exacerbating the psychosis with an increase in central dopaminergic tone.
Renal Dysfunction
Moderate:
opicapone
Opicapone has a moderate potential interaction with Renal Dysfunction.
The pharmacokinetics of opicapone have not been studied in patients with end stage renal disease. Caution is advised.
Syncope
Major:
flibanserin
Flibanserin has a major potential interaction with Syncope.
The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.
Report options
More resources
flibanserin
A total of 517 drugs are known to interact with flibanserin.
- Flibanserin is in the drug class miscellaneous central nervous system agents.
- Flibanserin is used to treat Hypoactive Sexual Desire Disorder.
opicapone
A total of 279 drugs are known to interact with opicapone.
- Opicapone is in the drug class dopaminergic antiparkinsonism agents.
- Opicapone is used to treat Parkinson's Disease.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.