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Can you take Flibanserin with Lonafarnib?

1 drug interaction and 8 additional warnings found for the following 2 drugs:

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Drug interactions

Major drug interactions

Major:

flibanserin lonafarnib

Applies to: flibanserin and lonafarnib

Using flibanserin together with lonafarnib is not recommended.

Combining these medications can significantly increase the blood levels of flibanserin, which may cause excessive drowsiness and decreases in blood pressure that can lead to:

  • dizziness
  • lightheadedness
  • fainting
  • accidental injury

You should take flibanserin at bedtime to minimize the risk of these effects.

Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

Major food/lifestyle interactions

Major:

flibanserin Food/Lifestyle

Applies to: flibanserin

Do not use alcohol too close to the dosing time of flibanserin. Doing so can cause excessive drowsiness and decreases in blood pressure, which may lead to:

  • dizziness
  • lightheadedness
  • fainting
  • accidental injury

What to do: Take flibanserin at bedtime to minimize the risk of these effects. It is recommended that you stop drinking alcohol at least two hours before taking flibanserin; otherwise, you should just skip the flibanserin dose that evening. Alcohol should not be consumed until at least the morning after taking flibanserin at bedtime.

Because grapefruit juice can significantly increase the blood levels of flibanserin, you should also avoid the consumption of grapefruit and grapefruit juice during treatment.

Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Major:

lonafarnib Food/Lifestyle

Applies to: lonafarnib

Consuming grapefruit, grapefruit juice, grapefruit hybrids, starfruit, and Seville oranges (also known as bitter or sour oranges) during treatment with lonafarnib is not recommended. Doing so may significantly increase the blood levels and effects of lonafarnib.

This may increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.

You may be more susceptible if you have:

  • a heart condition called congenital long QT syndrome
  • other cardiac diseases
  • conduction abnormalities
  • electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting)

The risk and/or severity of other side effects may also increase, including:

  • nausea
  • vomiting
  • diarrhea
  • loss of appetite
  • electrolyte (e.G., calcium, magnesium, potassium, phosphate, sodium) abnormalities
  • liver problems
  • low red and white blood cell counts
  • infection
  • high blood pressure

Additionally, you should take lonafarnib with the morning and evening meals and an adequate amount of water.

You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment.

Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Disease interactions

6 potential interactions Applies to: 5 conditions, including Hypotension, Syncope, Liver Disease, Alcoholism, and Renal Dysfunction.

Alcoholism

Major:

flibanserin

Flibanserin has a major potential interaction with Alcoholism.

The use of flibanserin is contraindicated along with the ingestion of alcohol, as it increases the risk of hypotension and syncope. It is important to assess the likelihood of the patient abstaining from alcohol, taking into account the current and past drinking behavior.

Hypotension

Major:

flibanserin

Flibanserin has a major potential interaction with Hypotension.

The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.

Liver Disease

Major:

flibanserin

Flibanserin has a major potential interaction with Liver Disease.

Flibanserin may accumulate in patients with hepatic impairment. Therapy with flibanserin is contraindicated in patients with compromised hepatic function.

Moderate:

lonafarnib

Lonafarnib has a moderate potential interaction with Liver Disease.

Hepatic transaminase elevations (i.e., aspartate aminotransferase AST] and alanine aminotransferase ([ALT]) have been reported during lonafarnib therapy. Often these elevations improve with continued therapy, but it is not possible to exclude this drug as a cause of the abnormalities. Liver enzymes should be monitored periodically during therapy.

Renal Dysfunction

Moderate:

lonafarnib

Lonafarnib has a moderate potential interaction with Renal Dysfunction.

Lonafarnib has not been studied in patients with renal impairment, however, this drug caused nephrotoxicity in rats at plasma drug exposures approximately equal to that achieved with the human dose. Renal function should be monitored at regular intervals during therapy.

Syncope

Major:

flibanserin

Flibanserin has a major potential interaction with Syncope.

The use of flibanserin can cause hypotension and syncope. The benefits and risks of therapy should be considered in patients with preexisting conditions that predispose to hypotension. Flibanserin should be used with caution in these patients.

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More resources

flibanserin

A total of 517 drugs are known to interact with flibanserin.

lonafarnib

A total of 710 drugs are known to interact with lonafarnib.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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