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Can you take Flavoxate with Panadol Gel Tabs?

1 drug interaction and 10 additional warnings found for the following 2 drugs:

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Drug interactions

Minor drug interactions

Minor:

acetaminophen flavoxATE

Applies to: Panadol Gel Tabs (acetaminophen) and flavoxate

Narcotic analgesics, anticholinergic agents, and/or agents with anticholinergic properties may delay and/or decrease the gastrointestinal absorption of acetaminophen (paracetamol) by reducing gastric motility and delaying gastric emptying. Available data suggest the clinical impact is minimal and generally does not necessitate dose adjustment.

The information above is from our professional interaction data. Consumer information is not available for this interaction.

Food/lifestyle interactions

Major food/lifestyle interactions

Major:

acetaminophen Food/Lifestyle

Applies to: Panadol Gel Tabs (acetaminophen)

Acetaminophen may cause liver damage and taking it with alcohol may increase that risk.

You should avoid or limit the use of alcohol while being treated with acetaminophen.

Call your doctor immediately if you have:

  • fever
  • chills
  • joint pain or swelling
  • excessive tiredness or weakness
  • unusual bleeding or bruising
  • skin rash or itching
  • loss of appetite
  • nausea
  • vomiting
  • dark colored urine
  • yellowing of the skin or the whites of your eyes

These may be symptoms of liver damage.

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Moderate food/lifestyle interactions

Moderate:

flavoxATE Food/Lifestyle

Applies to: flavoxate

Alcohol can increase the nervous system side effects of flavoxATE such as:

  • dizziness
  • drowsiness
  • difficulty concentrating

Some people may also experience impairment in thinking and judgment.

You should avoid or limit the use of alcohol while being treated with flavoxATE.

Do not use more than the recommended dose of flavoxATE, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you.

Talk to your doctor or pharmacist if you have any questions or concerns.

Disease interactions

8 potential interactions Applies to: 8 conditions, including Urinary Retention, Liver Disease, Dehydration, Glaucoma/Intraocular Hypertension, and Alcoholism.

Alcoholism

Major:

Panadol Gel Tabs

The acetaminophen in Panadol Gel Tabs has a major potential interaction with Alcoholism.

Chronic alcohol abusers may be at increased risk of hepatotoxicity during treatment with acetaminophen (APAP). Severe liver injury, including cases of acute liver failure resulting in liver transplant and death, has been reported in patients using acetaminophen. Therapy with acetaminophen should be administered cautiously, if at all, in patients who consume three or more alcoholic drinks a day. In general, patients should avoid drinking alcohol while taking acetaminophen-containing medications. Patients should be warned not to exceed the maximum recommended total daily dosage of acetaminophen (4 g/day in adults and children 12 years of age or older), and to read all prescription and over-the-counter medication labels to ensure they are not taking multiple acetaminophen-containing products, or check with a healthcare professional if they are unsure. They should also be advised to seek medical attention if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.

Dehydration

Major:

Panadol Gel Tabs

The acetaminophen in Panadol Gel Tabs has a major potential interaction with Dehydration.

Acetaminophen is contraindicated in patients with severe hepatic impairment or severe active liver disease. Patients with hepatic impairment may be at increased risk of toxicity. Severe liver injury, including cases of acute liver failure and death, have been reported in patients using this drug. Clinical monitoring of hepatic function is recommended. Caution is advised if using acetaminophen in patients with chronic malnutrition or severe hypovolemia. Instruct patients to avoid drinking alcohol while taking acetaminophen-containing medications. Patients should be warned not to exceed the maximum recommended total daily dosage of acetaminophen (4 g/day in adults and children 12 years of age or older), and to read all prescription and over-the-counter medication labels to ensure they are not taking multiple acetaminophen-containing products, or check with a healthcare professional if they are unsure.

Gastrointestinal Obstruction

Major:

flavoxate

flavoxATE has a major potential interaction with Gastrointestinal Obstruction.

The use of flavoxate is contraindicated in patients with GI obstruction, ileus, atony, and obstructive uropathy. Flavoxate exerts direct antispasmodic effects on smooth muscles and possesses weak anticholinergic activity.

Glaucoma/Intraocular Hypertension

Moderate:

flavoxate

flavoxATE has a moderate potential interaction with Glaucoma/Intraocular Hypertension.

Flavoxate exerts mydriatic activity that can induce increased intraocular pressure and result in angle-closure (narrow angle) glaucoma. Therapy with flavoxate should be administered cautiously in patients with angle-closure glaucoma.

Liver Disease

Major:

Panadol Gel Tabs

The acetaminophen in Panadol Gel Tabs has a major potential interaction with Liver Disease.

Acetaminophen is contraindicated in patients with severe hepatic impairment or severe active liver disease. Patients with hepatic impairment may be at increased risk of toxicity. Severe liver injury, including cases of acute liver failure and death, have been reported in patients using this drug. Clinical monitoring of hepatic function is recommended. Caution is advised if using acetaminophen in patients with chronic malnutrition or severe hypovolemia. Instruct patients to avoid drinking alcohol while taking acetaminophen-containing medications. Patients should be warned not to exceed the maximum recommended total daily dosage of acetaminophen (4 g/day in adults and children 12 years of age or older), and to read all prescription and over-the-counter medication labels to ensure they are not taking multiple acetaminophen-containing products, or check with a healthcare professional if they are unsure.

Malnourishment

Major:

Panadol Gel Tabs

The acetaminophen in Panadol Gel Tabs has a major potential interaction with Malnourishment.

Acetaminophen is contraindicated in patients with severe hepatic impairment or severe active liver disease. Patients with hepatic impairment may be at increased risk of toxicity. Severe liver injury, including cases of acute liver failure and death, have been reported in patients using this drug. Clinical monitoring of hepatic function is recommended. Caution is advised if using acetaminophen in patients with chronic malnutrition or severe hypovolemia. Instruct patients to avoid drinking alcohol while taking acetaminophen-containing medications. Patients should be warned not to exceed the maximum recommended total daily dosage of acetaminophen (4 g/day in adults and children 12 years of age or older), and to read all prescription and over-the-counter medication labels to ensure they are not taking multiple acetaminophen-containing products, or check with a healthcare professional if they are unsure.

Phenylketonuria

Moderate:

Panadol Gel Tabs

The acetaminophen in Panadol Gel Tabs has a moderate potential interaction with Phenylketonuria.

Several oral acetaminophen and acetaminophen-combination products, particularly flavored chewable tablets, contain the artificial sweetener, aspartame (NutraSweet). Aspartame is converted to phenylalanine in the gastrointestinal tract following ingestion. Chewable and effervescent formulations of acetaminophen products may also contain phenylalanine. The aspartame/phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics).

Urinary Retention

Major:

flavoxate

flavoxATE has a major potential interaction with Urinary Retention.

The use of flavoxate is contraindicated in patients with GI obstruction, ileus, atony, and obstructive uropathy. Flavoxate exerts direct antispasmodic effects on smooth muscles and possesses weak anticholinergic activity.

More resources

flavoxate

A total of 344 drugs are known to interact with flavoxate.

Panadol Gel Tabs

A total of 540 drugs are known to interact with Panadol Gel Tabs.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.