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Drug Interactions between finasteride and terazosin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

terazosin finasteride

Applies to: terazosin and finasteride

Study data (n=90) reported a statistically significant interaction between finasteride and terazosin affecting finasteride pharmacokinetics, but not those of terazosin. Treatment with terazosin (45 days) and finasteride (10 days) resulted in a finasteride Cmax and AUC(0-24) significantly greater than for finasteride alone. The clinical significance of this interaction remains to be determined. Earlier data (n=48) failed to reveal significant pharmacokinetic or pharmacodynamic alterations in either drug when administered concurrently. No special precautions are recommended at this time.

References (2)
  1. Samara EE, Hosmane B, Locke C, Eason C, Cavanaugh J, Granneman GR (1996) "Assessment of the pharmacokinetic-pharmacodynamic interaction between terazosin and finasteride." J Clin Pharmacol, 36, p. 1169-78
  2. Vashi V, Chung M, Hilbert J, Lawrence V, Phillips K (1998) "Pharmacokinetic interaction between finasteride and terazosin, but not finasteride and doxazosin." J Clin Pharmacol, 38, p. 1072-6

Drug and food interactions

Moderate

terazosin food

Applies to: terazosin

GENERALLY AVOID: The concurrent use of ethanol and alpha-1 adrenergic blockers may cause increased hypotensive effects. Patients with aldehyde dehydrogenase deficiencies (primarily Asians) may be at a higher risk of this interaction. The mechanism has not been determined. Data exist for prazosin and other alpha adrenergic blockers are expected to interact also. In addition, any patients taking alpha adrenergic blockers may experience excessive orthostatic hypotension with ethanol ingestion, due to ethanol's unopposed vasodilatory effects in the presence of alpha adrenergic blockade.

MANAGEMENT: Patients who develop a flushing reaction after ethanol ingestion (indicates a possible aldehyde dehydrogenase deficiency) should be advised to avoid ethanol or limit their intake. All patients should be warned about the possibility of orthostatic hypotension with concurrent ethanol use.

References (2)
  1. Kawano Y, Abe H, Kojima S, Takishita S, Omae T (2000) "Interaction of alcohol and an a1-blocker on ambulatory blood pressure in patients with essential hypertension." Am J Hypertens, 13, p. 307-12
  2. (2002) "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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