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Drug Interactions between febuxostat and Lufyllin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dyphylline febuxostat

Applies to: Lufyllin (dyphylline) and febuxostat

MONITOR: Coadministration with febuxostat may alter the pharmacokinetics of theophylline. The proposed mechanism is inhibition of xanthine oxidase by febuxostat. In healthy volunteers, administration of theophylline in combination with febuxostat 80 mg once daily resulted in a 6% increase in theophylline peak plasma concentration (Cmax) and a 6.5% increase in systemic exposure (AUC). These changes were not considered statistically or clinically significant. However, the study also showed an approximately 400-fold increase in the urinary excretion of 1-methylxanthine, one of the major theophylline metabolites. The safety of long-term exposure to 1-methylxanthine has not been evaluated.

MANAGEMENT: No dosage adjustment is necessary for theophylline when coadministered with febuxostat, but caution is advised. Because the safety of long-term exposure to 1-methylxanthine is unknown, this should be taken into consideration when deciding to use the combination.

References

  1. (2009) "Product Information. Uloric (febuxostat)." Takeda Pharmaceuticals America

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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