Drug Interactions between Exparel and mexiletine
This report displays the potential drug interactions for the following 2 drugs:
- Exparel (bupivacaine liposome)
- mexiletine
Interactions between your drugs
mexiletine BUPivacaine liposome
Applies to: mexiletine and Exparel (bupivacaine liposome)
BUPivacaine liposome is a specially formulated anesthetic that releases the medication into the surrounding tissue at a controlled rate. When exposed to other local anesthetic solutions, the release rate can be altered. Therefore, BUPivacaine liposome and mexiletine should not be mixed together or injected into the same area at the same time, as it may cause rapid release of the active medication and alter the safety and efficacy of BUPivacaine liposome. Additional use of local anesthetics including mexiletine should generally be avoided within 96 hours following administration of BUPivacaine liposome. If necessary, BUPivacaine liposome may be locally administered after at least 20 minutes following the local administration of lidocaine. However, there are currently no data to support administration of other local, non-bupivacaine based anesthetics prior to administration of BUPivacaine liposome. Because the toxic effects of these medications are additive, using them together requires caution and constant monitoring of vital signs and state of consciousness to prevent serious and potentially life-threatening side effects such as methemoglobinemia (a condition that can deprive tissues and organs of oxygen), central nervous system reactions (e.G., convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.G., low blood pressure, heart block, irregular heart rhythm, cardiac arrest). Patients require immediate medical attention if they develop signs and symptoms of methemoglobinemia such as pale, gray, or blue colored skin (cyanosis); headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue.
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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