Interactions between Evalose and Oxytocin
1 drug interaction and 7 additional warnings found for the following 2 drugs:
- Evalose (lactulose)
- oxytocin
Drug interactions
Moderate drug interactions
Moderate:
oxytocin lactulose
Applies to: oxytocin and Evalose (lactulose)
Monitor
Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in patients treated with drugs that prolong the QT interval. Electrolyte disturbances including hypokalemia and hypomagnesemia have been reported with laxative abuse and are known risk factors for torsade de pointes associated with QT interval prolongation.
Management
Patients treated with drugs that prolong the QT interval should exercise caution when self-medicating with laxatives. The recommended dosage and duration of use should not be exceeded. Patients treated with lactulose for more than six months should be monitored periodically for electrolyte imbalance. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
References (4)
- Chin RL (1998) "Laxative-induced hypokalemia." Ann Emerg Med, 32, p. 517-8
- Muller-Lissner SA (1993) "Adverse effects of laxatives: fact and fiction." Pharmacology, 47, p. 138-45
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Schaefer DC, Cheskin LJ (1998) "Constipation in the elderly." Am Fam Physician, 58, p. 907-14
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
7 potential interactions Applies to: 7 conditions, including High Blood Pressure, Inflammatory Bowel Disease, Diabetes Mellitus, Fluid Retention, and Galactosemia.
Cerebral Vascular Disorder
Moderate:
oxytocin
Oxytocin has a moderate potential interaction with Cerebral Vascular Disorder.
Hypertensive events, subarachnoid hemorrhage, and arrhythmias have occurred during oxytocin therapy. Oxytocin possesses presser activity. Caution is advised in patients with uncontrolled hypertension or cerebrovascular dysfunction.
Diabetes Mellitus
Moderate:
Evalose
The lactulose in Evalose has a moderate potential interaction with Diabetes Mellitus.
Since lactulose solution contains galactose and lactose, it should be used cautiously in patients with diabetes.
Fluid Retention
Moderate:
oxytocin
Oxytocin has a moderate potential interaction with Fluid Retention.
Volume overload can occur during administration of oxytocin. Oxytocin possess antidiuretic properties. Consideration should, therefore, be given to the possibility of volume overload and water intoxication, particularly when oxytocin is administered continuously by infusion and the patient is receiving fluids by mouth.
Galactosemia
Major:
Evalose
The lactulose in Evalose has a major potential interaction with Galactosemia.
Since lactulose solution contains galactose, use is contraindicated in patients who require a low galactose diet.
Gastrointestinal Obstruction
Major:
Evalose
The lactulose in Evalose has a major potential interaction with Gastrointestinal Obstruction.
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
High Blood Pressure
Moderate:
oxytocin
Oxytocin has a moderate potential interaction with High Blood Pressure.
Hypertensive events, subarachnoid hemorrhage, and arrhythmias have occurred during oxytocin therapy. Oxytocin possesses presser activity. Caution is advised in patients with uncontrolled hypertension or cerebrovascular dysfunction.
Inflammatory Bowel Disease
Major:
Evalose
The lactulose in Evalose has a major potential interaction with Inflammatory Bowel Disease.
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
Report options
More resources
Evalose
A total of 273 drugs are known to interact with Evalose.
- Evalose is in the drug class laxatives.
- Evalose is used to treat the following conditions:
oxytocin
A total of 279 drugs are known to interact with oxytocin.
- Oxytocin is in the drug class uterotonic agents.
- Oxytocin is used to treat the following conditions:
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.