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Drug Interactions between eravacycline and Xiaflex

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

collagenase clostridium histolyticum eravacycline

Applies to: Xiaflex (collagenase clostridium histolyticum) and eravacycline

MONITOR: Tetracycline antibiotics may inhibit the metalloproteinase-mediated collagen degradation of collagenase clostridium histolyticum (CCH). There is not any clinical evidence of an interaction between CCH and tetracycline antibiotics in vivo. However, some sources report that tetracyclines have been shown to inhibit matrix metalloproteinase-mediated collagen degradation at pharmacologically relevant concentrations in vitro, while others report that this inhibition takes place at supra-pharmacological concentrations in vitro. There is also some research, using animal models, into the possibility of giving oral doxycycline prior to CCH-injections to help prevent skin injury.

MANAGEMENT: Collagenase clostridium histolyticum (CCH) should be used with caution in patients receiving tetracyclines as they could reduce the efficacy of CCH injections. Some authorities recommend not administering CCH to patients who have received tetracycline antibiotics within the previous 14 days.

References (3)
  1. (2019) "Product Information. Xiaflex (collagenase clostridium histolyticum)." Endo Laboratories LLC
  2. (2016) "Product Information. Xiapex (kollagenas, Clostridium histolyticum)." Swedish Orphan Biovitrum AB (publ)
  3. Diehm YF, Kotsougiani-Fischer D, Porst E, et al. (2023) Oral doxycycline prevents skin-associated adverse effects induced by injectable collagenase in a rodent model of capsular contracture around silicone implants. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258873/

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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