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Drug Interactions between enzalutamide and Xarelto

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

rivaroxaban enzalutamide

Applies to: Xarelto (rivaroxaban) and enzalutamide

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 or dual P-glycoprotein (P-gp) and potent CYP450 3A4 inducers may significantly decrease the plasma concentrations of rivaroxaban, which is a substrate of the isoenzyme and of the efflux transporter. In a pharmacokinetic study, administration of a single 20 mg dose of rivaroxaban with the dual P-gp and potent CYP450 3A4 inducer rifampin (titrated up to 600 mg once daily) resulted in approximately 22% and 50% decreases in mean rivaroxaban peak plasma concentration (Cmax) and system exposure (AUC), respectively, with parallel decreases in its pharmacodynamic effects.

MANAGEMENT: Concomitant use of rivaroxaban with potent CYP450 3A4 inducers or dual P-gp and potent CYP450 3A4 inducers should generally be avoided.

References (4)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  3. Cerner Multum, Inc. "Australian Product Information."
  4. (2008) "Product Information. Xarelto (rivaroxaban)." Bayer Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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