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Drug Interactions between Effient and MHP-A

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

phenyl salicylate prasugrel

Applies to: MHP-A (hyoscyamine / methenamine / methylene blue / phenyl salicylate) and Effient (prasugrel)

MONITOR: Concomitant use of prasugrel with other agents that affect hemostasis including aspirin may increase the risk of bleeding. According to the product labeling, the effects of prasugrel on platelet aggregation were not significantly affected by aspirin 150 mg daily. However, bleeding time was increased compared with either drug alone. The safety of prasugrel during coadministration with other salicylates has not been established, but potentiation of gastrointestinal bleeding should be considered.

MANAGEMENT: Although prasugrel may be used with aspirin, caution is advised during coadministration with any salicylate, especially in patients at risk for gastrointestinal ulceration or bleeding. Close clinical and laboratory observation for hemorrhagic complications is recommended. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, bloating, dizziness, lightheadedness, hematemesis, anorexia, and/or black, tarry stools.

References

  1. (2009) "Product Information. Effient (prasugrel)." Lilly, Eli and Company

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Drug and food interactions

Moderate

hyoscyamine food

Applies to: MHP-A (hyoscyamine / methenamine / methylene blue / phenyl salicylate)

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References

  1. Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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