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Drug Interactions between doxorubicin and melphalan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

DOXOrubicin melphalan

Applies to: doxorubicin and melphalan

Limited anecdotal data suggest an increased risk of doxorubicin-induced cardiomyopathy in patients who have previously received melphalan. The mechanism of this suspected interaction is unknown. Although conclusive proof that melphalan sensitizes the myocardium is lacking, anthracyclines should be administered cautiously to patients who have had extensive melphalan therapy.

References (1)
  1. Bitran JD (1981) "Doxorubicin cardiotoxicity and melphalan" Ann Intern Med, 95, p. 243-4

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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