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Drug Interactions between Doc-Q-Lax and phenolphthalein

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

phenolphthalein docusate

Applies to: phenolphthalein and Doc-Q-Lax (docusate / senna)

GENERALLY AVOID: Docusate may increase the toxicity of phenolphthalein by increasing intestinal absorption of the drug.

MANAGEMENT: Concomitant use of docusate and phenolphthalein should be avoided.

References (1)
  1. (2001) "Product Information. Colace (docusate)." Roberts Pharmaceutical Corporation

Drug and food/lifestyle interactions

Moderate

phenolphthalein food/lifestyle

Applies to: phenolphthalein

GENERALLY AVOID: Chronic use of stimulant laxatives may decrease the absorption of fat-soluble vitamins (A, D, E, and K) and minerals such as calcium, potentially leading to deficiencies. This effect is due to accelerated intestinal transit time, which reduces nutrient absorption.

MANAGEMENT: To minimize this risk, limit the use of stimulant laxatives to short-term or occasional use.

References (2)
  1. (2023) "Product Information. Domnisol (calcifediol)." Flynn Pharma Ltd
  2. Wakeman M (2021) "A Literature Review of the Potential Impact of Medication on Vitamin D Status" Risk Man Heal Pol, 14, p. 3357-3381
Moderate

senna food/lifestyle

Applies to: Doc-Q-Lax (docusate/senna)

GENERALLY AVOID: Chronic use of stimulant laxatives may decrease the absorption of fat-soluble vitamins (A, D, E, and K) and minerals such as calcium, potentially leading to deficiencies. This effect is due to accelerated intestinal transit time, which reduces nutrient absorption.

MANAGEMENT: To minimize this risk, limit the use of stimulant laxatives to short-term or occasional use.

References (2)
  1. (2023) "Product Information. Domnisol (calcifediol)." Flynn Pharma Ltd
  2. Wakeman M (2021) "A Literature Review of the Potential Impact of Medication on Vitamin D Status" Risk Man Heal Pol, 14, p. 3357-3381

Disease interactions

Major

senna Appendicitis

Applies to: Appendicitis

The use of stimulant laxatives is contraindicated in patients with or who may have acute surgical abdomen or appendicitis. These patients may be candidates for emergency surgery. Stimulant laxatives should also not be administered to patients with abdominal pain, particularly if the cause has not been determined.

Major

senna Bleeding

Applies to: Bleeding

The use of stimulant laxatives is contraindicated in patients with anal or rectal fissures. These preparations may cause irritation, burning sensation, and proctitis.

Major

phenolphthalein Gastrointestinal Obstruction

Applies to: Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

Major

senna Gastrointestinal Obstruction

Applies to: Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

Major

docusate Gastrointestinal Obstruction

Applies to: Gastrointestinal Obstruction

The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.

Major

phenolphthalein Inflammatory Bowel Disease

Applies to: Inflammatory Bowel Disease

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

Major

senna Inflammatory Bowel Disease

Applies to: Inflammatory Bowel Disease

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

Major

docusate Inflammatory Bowel Disease

Applies to: Inflammatory Bowel Disease

The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Stimulant laxatives

Therapeutic duplication

The recommended maximum number of medicines in the 'stimulant laxatives' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'stimulant laxatives' category:

  • Doc-Q-Lax (docusate/senna)
  • phenolphthalein

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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