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Drug Interactions between Diltiazem Hydrochloride XT and hydrochlorothiazide

This report displays the potential drug interactions for the following 2 drugs:

  • Diltiazem Hydrochloride XT (diltiazem)
  • hydrochlorothiazide

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Interactions between your drugs

No interactions were found between Diltiazem Hydrochloride XT and hydrochlorothiazide. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Diltiazem Hydrochloride XT

A total of 627 drugs are known to interact with Diltiazem Hydrochloride XT.


A total of 421 drugs are known to interact with hydrochlorothiazide.

Drug and food interactions


dilTIAZem food

Applies to: Diltiazem Hydrochloride XT (diltiazem)

Alcohol can lower your blood pressure and add to the effects of dilTIAZem. You may experience dizziness, lightheadedness, fainting, or a rapid heartbeat if you drink alcohol with dilTIAZem, especially when you first start taking the medication or just after a dose increase. Grapefruit juice may also increase the effects of dilTIAZem in some people by increasing its levels in the blood. You may want to limit alcohol intake and avoid excessive consumption of grapefruit and grapefruit juice during treatment with dilTIAZem. However, if you have been regularly consuming grapefruit or grapefruit juice with dilTIAZem, do not alter the amounts of these products in your diet without first talking to your doctor or other healthcare professional. Contact your doctor if your condition changes or you experience increased side effects of dilTIAZem such as headache, irregular heartbeat, swelling, unexplained weight gain, or chest pain. Orange juice is not expected to interact.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.