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Drug Interactions between diclofenac and gemfibrozil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

gemfibrozil diclofenac

Applies to: gemfibrozil and diclofenac

MONITOR: Coadministration with inhibitors of CYP450 2C9 may increase the plasma concentrations of diclofenac, which is primarily metabolized by the isoenzyme. When the last dose of CYP450 2C9 inhibitor voriconazole (400 mg every 12 hours on day 1, followed by 200 mg every 12 hours on day 2) was coadministered with a single dose of diclofenac (50 mg), the peak plasma concentration (Cmax) and systemic exposure (AUC) of diclofenac increased by 114% and 78%, respectively, compared to diclofenac alone.

MANAGEMENT: Caution is advised if diclofenac is prescribed in combination with an inhibitor of CYP450 2C9. Some authorities recommend a reduction of the maximum diclofenac dose to 100 mg per day when coadministered with a CYP450 2C9 inhibitor.

References (3)
  1. (2001) "Product Information. Arthrotec (diclofenac-misoprostol)." Searle
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

Moderate

diclofenac food

Applies to: diclofenac

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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