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Drug Interactions between Di-Spaz and nitrofurantoin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

nitrofurantoin dicyclomine

Applies to: nitrofurantoin and Di-Spaz (dicyclomine)

Anticholinergic agents may increase the absorption and oral bioavailability of nitrofurantoin. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline 45 minutes before a single 100 mg dose of nitrofurantoin significantly increased the oral bioavailability of nitrofurantoin as indicated by a 68% increase in urinary recovery. In another study, atropine 500 mcg given subcutaneously one-half hour before a single 100 mg dose of nitrofurantoin delayed the absorption and urinary excretion of nitrofurantoin but did not affect its overall bioavailability in ten healthy volunteers. The clinical significance of these changes is unknown.

References

  1. Mannisto P (1978) "The effect of crystal size, gastric content and emptying rate on the absorption of nitrofurantoin in healthy human volunteers." Int J Clin Pharmacol Biopharm, 16, p. 223-8
  2. Jaffe JM (1975) "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci, 64, p. 1729-30

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Drug and food interactions

Moderate

dicyclomine food

Applies to: Di-Spaz (dicyclomine)

GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

References

  1. Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.