Skip to main content

Drug Interactions between Demser and V-Gan-50

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

metyroSINE promethazine

Applies to: Demser (metyrosine) and V-Gan-50 (promethazine)

MONITOR: Coadministration of metyrosine in combination with haloperidol, phenothiazines, or other dopamine antagonists may increase the risk of extrapyramidal disorders. Extrapyramidal effects have been reported during metyrosine therapy. The mechanism is inhibition of catecholamine synthesis by metyrosine. In addition, sedative effects of both drugs may be increased.

MANAGEMENT: When concurrent use is required, patients should be monitored for extrapyramidal symptoms and instructed to notify their physician if they experience symptoms such as bradykinesia, hypertonia, rigidity, restlessness, and dysphagia. Patients should also avoid driving or operating hazardous machinery until they know how the medications affect them.

References

  1. "Product Information. Demser (metyrosine)." Merck & Co., Inc PROD (2001):

Switch to consumer interaction data

Drug and food interactions

Moderate

metyroSINE food

Applies to: Demser (metyrosine)

MONITOR: Metyrosine, when coadministered with other CNS depressants including alcoholic beverages, may lead to excessive somnolence and other forms of nervous system depression.

MANAGEMENT: The patient should be informed to use caution if these agents are coadministered, especially if performing hazardous tasks such as driving or operating machinery.

References

  1. "Product Information. Demser (metyrosine)." Merck & Co., Inc PROD (2001):

Switch to consumer interaction data

Moderate

promethazine food

Applies to: V-Gan-50 (promethazine)

GENERALLY AVOID: Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment. Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines. The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.

MANAGEMENT: Patients should be advised to avoid alcohol during phenothiazine therapy.

References

  1. Lutz EG "Neuroleptic-induced akathisia and dystonia triggered by alcohol." JAMA 236 (1976): 2422-3
  2. Freed E "Alcohol-triggered-neuroleptic-induced tremor, rigidity and dystonia." Med J Aust 2 (1981): 44-5

Switch to consumer interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer