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Drug Interactions between delavirdine and modafinil

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

delavirdine modafinil

Applies to: delavirdine and modafinil

MONITOR: Coadministration with modafinil (the racemate) or armodafinil (the R-enantiomer) may decrease the plasma concentrations of delavirdine due to induction of CYP450 3A4 metabolism. Conversely, delavirdine may increase the plasma concentrations of modafinil due to inhibition of CYP450 3A4. The clinical significance is unknown. Modafinil and armodafinil are modest CYP450 3A4 inducers in vitro, while delavirdine is considered a potent inhibitor of the isoenzyme.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with decreased or subtherapeutic antiretroviral drug levels, caution is advised if modafinil or armodafinil must be used in patients treated with delavirdine. Clinical monitoring for altered effects of both drugs may be appropriate following addition or withdrawal of one or the other drug.

References (4)
  1. (2001) "Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn
  2. (2001) "Product Information. Provigil (modafinil)." Cephalon, Inc
  3. Robertson P, Decory HH, Madan A, Parkinson A (2000) "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos, 28, p. 664-71
  4. (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc

Drug and food interactions

Minor

modafinil food

Applies to: modafinil

Administration with food may delay the absorption of modafinil (the racemate) and armodafinil (the R-enantiomer) without significantly affecting their overall bioavailability. According to the product labeling, modafinil's absorption may be delayed by approximately one hour if taken with food. Similarly, the time to reach peak plasma concentration (Tmax) of armodafinil may be delayed by approximately 2 to 4 hours in the fed state.

References (2)
  1. (2001) "Product Information. Provigil (modafinil)." Cephalon, Inc
  2. (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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