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Can you take Defibrotide with Plasminogen, human?

1 drug interaction and 1 additional warning found for the following 2 drugs:

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Drug interactions

Major drug interactions

Major:

defibrotide plasminogen, human

Applies to: defibrotide and plasminogen, human

Using plasminogen, human together with defibrotide may increase the risk of bleeding.

Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications.

You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as:

  • dizziness
  • lightheadedness
  • red or black, tarry stools
  • coughing up or vomiting fresh or dried blood that looks like coffee grounds
  • severe headache
  • weakness

It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

1 potential interaction Applies to: 1 condition, including Bleeding Disorder.

Bleeding Disorder

Major:

defibrotide

Defibrotide has a major potential interaction with Bleeding Disorder.

The use of defibrotide may increase the risk of bleeding in patients with hepatic veno-occlusive disease after hematopoietic stem-cell transplantation. Discontinue anticoagulants and fibrinolytic agents prior to defibrotide treatment, and consider delaying the start of defibrotide administration until the effects of the anticoagulant have subsided. It is recommended to withhold therapy with defibrotide in patients with active bleeding and to monitor patients for signs of bleeding. Discontinue treatment with defibrotide in patients that develop bleeding and treat the underlying cause, and provide supportive care until the bleeding has stopped.

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More resources

defibrotide

A total of 151 drugs are known to interact with defibrotide.

plasminogen, human

A total of 77 drugs are known to interact with plasminogen, human.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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