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Drug Interactions between dapsone and Primsol

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

dapsone trimethoprim

Applies to: dapsone and Primsol (trimethoprim)

MONITOR: Serum levels of both trimethoprim and dapsone may be increased during coadministration. The mechanism is unknown. Steady state levels are reached within approximately one week.

MANAGEMENT: When these agents are coadministered, monitoring for methemoglobinemia may be important, especially in patients with respiratory insufficiency, anemia, or cardiovascular disease.

References (4)
  1. Lee B, Medina I, Benowitz N, et al. (1989) "Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med, 110, p. 606-11
  2. McKinsey D, Durfee D, Kurtin P (1989) "Megaloblastic pancytopenia associated with dapsone and trimethorprim treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome." Arch Intern Med, 149, p. 965
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  4. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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