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Drug Interactions between daclatasvir and simeprevir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

simeprevir daclatasvir

Applies to: simeprevir and daclatasvir

MONITOR: Coadministration with simeprevir may increase the plasma concentrations of daclatasvir. The proposed mechanism of interaction is simeprevir inhibition of the intestinal and/or renal efflux of daclatasvir via P-glycoprotein. When daclatasvir 60 mg once daily was administered with simeprevir 150 mg once daily, daclatasvir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) increased by 50%, 96% and 168%, respectively. Simeprevir Cmax, AUC and Cmin also increased by 39%, 44% and 49%, respectively, due to inhibition of OATP1B1-mediated hepatic uptake by daclatasvir.

MANAGEMENT: Caution is advised when daclatasvir is used with simeprevir. Patients should be monitored for adverse effects such as headache, fatigue, nausea, diarrhea, and serum lipase elevations.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2015) "Product Information. Daklinza (daclatasvir)." Bristol-Myers Squibb

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Drug and food interactions

Moderate

simeprevir food

Applies to: simeprevir

ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of simeprevir, although the type of food does not seem to matter. In healthy study subjects, administration of simeprevir after a high-fat, high-caloric (928 kcal) breakfast increased systemic exposure (AUC) by 61% and delayed absorption by 1 hour, while administration after a normal caloric (533 kcal) breakfast increased AUC by 69% and delayed absorption by 1.5 hours.

MANAGEMENT: To ensure maximal oral absorption, simeprevir should be administered with food.

References

  1. (2013) "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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