Drug Interactions between dabrafenib and ipilimumab
This report displays the potential drug interactions for the following 2 drugs:
- dabrafenib
- ipilimumab
Interactions between your drugs
No interactions were found between dabrafenib and ipilimumab. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
dabrafenib
A total of 473 drugs are known to interact with dabrafenib.
- Dabrafenib is in the drug class multikinase inhibitors.
- Dabrafenib is used to treat the following conditions:
ipilimumab
A total of 152 drugs are known to interact with ipilimumab.
- Ipilimumab is in the drug class anti-CTLA-4 monoclonal antibodies.
- Ipilimumab is used to treat the following conditions:
Drug and food interactions
dabrafenib food
Applies to: dabrafenib
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of dabrafenib. In study subjects, administration of dabrafenib with a high-fat meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 51% and 31%, respectively, and delayed median Tmax by approximately 3.6 hours compared to administration in the fasted state.
MANAGEMENT: Dabrafenib should be taken at least 1 hour before or 2 hours after a meal.
References
- "Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline (2013):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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