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Drug Interactions between cyclophosphamide and indomethacin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

cycloPHOSphamide indomethacin

Applies to: cyclophosphamide and indomethacin

A single case report suggests that the combination of cyclophosphamide and indomethacin may cause serious hyponatremia. It is well known that cyclophosphamide alone can cause hyponatremia by causing a renal tubular concentrating defect, as well as a syndrome that resembles the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Indomethacin may contribute to acute water intoxication by inhibiting synthesis of prostaglandins (which are important in maintaining water and electrolyte homeostasis and renal blood flow). However, it is not known whether indomethacin or other nonsteroidal anti-inflammatory drugs (NSAIDs) potentiate any side effects from cyclophosphamide. More data are needed.

References (1)
  1. Webberley MJ, Murray JA (1989) "Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin." Postgrad Med J, 65, p. 950-2

Drug and food interactions

Moderate

indomethacin food

Applies to: indomethacin

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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