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Drug Interactions between creatine and trimethoprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

trimethoprim creatine

Applies to: trimethoprim and creatine

Cimetidine, trimethoprim, and probenecid are all known to interfere with the kidney's secretion of creatinine. Administration of creatine supplements to patients on these medications may lead to an increase in the serum level of these drugs and/or of creatinine. The physician should be aware that these increased serum levels may occur, and dosages may need to be adjusted or creatine supplementation may need to be discontinued as necessary.

References (1)
  1. Vandenberghe K, Gosris M, Van Hecke PV, Van Leemputte M, Vangerven L, Hespel P (1997) "Long-term creatine intake is beneficial to muscle performance during resistance training." J Appl Physiol, 83, p. 2055-63

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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