Drug Interactions between Cotellic and tamsulosin
This report displays the potential drug interactions for the following 2 drugs:
- Cotellic (cobimetinib)
- tamsulosin
Interactions between your drugs
No interactions were found between Cotellic and tamsulosin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Cotellic
A total of 368 drugs are known to interact with Cotellic.
- Cotellic is in the drug class multikinase inhibitors.
- Cotellic is used to treat the following conditions:
tamsulosin
A total of 293 drugs are known to interact with tamsulosin.
- Tamsulosin is in the drug class alpha blockers.
-
Tamsulosin is used to treat the following conditions:
- Benign Prostatic Hyperplasia
- Urinary Tract Stones (off-label)
Drug and food interactions
tamsulosin food
Applies to: tamsulosin
ADJUST DOSING INTERVAL: Food may delay the gastrointestinal absorption of tamsulosin. The time to maximum plasma concentration (Tmax) is reached by 4 to 5 hours under fasted conditions and by 6 to 7 hours when tamsulosin is administered with food. The delay in Tmax has the desirable effect of smoothing the tamsulosin plasma concentration profile, thereby reducing fluctuation of the plasma peak and trough concentrations with multiple dosing. Food may also affect the extent of absorption of tamsulosin. It has been reported that taking tamsulosin under fasted conditions results in a 30% increase in bioavailability (AUC) and 40% to 70% increase in peak plasma concentration (Cmax) compared to fed conditions. The effects of food on the pharmacokinetics of tamsulosin are consistent regardless of whether tamsulosin is taken with a light meal or a high-fat meal.
MANAGEMENT: To ensure uniformity of absorption, tamsulosin should be administered approximately one-half hour following the same meal each day.
References
- (2001) "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim
cobimetinib food
Applies to: Cotellic (cobimetinib)
MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme, such as cobimetinib. However, the interaction seems to affect primarily those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability), presumably due to the fact that grapefruit juice inhibits primarily intestinal rather than hepatic CYP450 3A4. Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of cobimetinib. Grapefruit and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact with these drugs.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2015) "Product Information. Cotellic (cobimetinib)." Genentech
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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