Can you take Cold & Hot with Fosaprepitant?

1 drug interaction and 1 additional warning found for the following 2 drugs:

Cold & Hot (menthol topical)
fosaprepitant

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Drug interactions

Minor drug interactions

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menthol topical fosaprepitant

Applies to: Cold & Hot (menthol topical) and fosaprepitant

Coadministration with orally administered menthol may decrease plasma concentrations of drugs that are substrates of the CYP450 3A4 and/or CYP450 2C9 isoenzymes. The proposed mechanism is increased clearance due to menthol-mediated induction of CYP450 3A4 and CYP450 2C9. In vivo data suggests that concomitant administration of oral menthol reduced the systemic exposure (AUC) of triazolam (a CYP450 3A4 substrate) by 40%, and phenytoin (a CYP450 2C9 substrate) by 20%. Until further data are available, no specific precautions are recommended.

The information above is from our professional interaction data. Consumer information is not available for this interaction.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

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1 potential interaction Applies to: 1 condition, including Liver Disease.

Liver Disease

fosaprepitant

Fosaprepitant has a moderate potential interaction with Liver Disease.

There are no clinical or pharmacokinetic data in patients with severe liver dysfunction (Child-Pugh score greater than 9); therefore, caution and additional monitoring for adverse reactions are recommended when using fosaprepitant in these patients.

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Cold & Hot

A total of 364 drugs are known to interact with Cold & Hot.

Cold & hot is in the drug class topical rubefacient.
Cold & hot is used to treat Pain.

fosaprepitant

A total of 472 drugs are known to interact with fosaprepitant.

Fosaprepitant is in the drug class NK1 receptor antagonists.
Fosaprepitant is used to treat the following conditions:
- Nausea/Vomiting
- Nausea/Vomiting, Chemotherapy Induced

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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