Drug Interactions between cobicistat and Crestor
This report displays the potential drug interactions for the following 2 drugs:
- cobicistat
- Crestor (rosuvastatin)
Interactions between your drugs
rosuvastatin cobicistat
Applies to: Crestor (rosuvastatin) and cobicistat
MONITOR: Coadministration with cobicistat may increase the plasma concentrations of rosuvastatin. The proposed mechanism is cobicistat inhibition of the OATP1B1-mediated hepatic uptake of rosuvastatin. In 10 healthy volunteers, administration of a single 10 mg dose of rosuvastatin in combination with a 150 mg dose each of cobicistat and elvitegravir increased mean rosuvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) by 89% and 38%, respectively. High levels of HMG-CoA reductase inhibitory activity in plasma is associated with an increased risk of musculoskeletal toxicity. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase exceeding ten times the upper limit of normal has been reported occasionally. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.
MANAGEMENT: Caution is advised if rosuvastatin is prescribed with cobicistat. The lowest starting dosage of rosuvastatin is recommended, then titrated as needed based on clinical response and tolerance. According to some authorities, the dose of rosuvastatin should not exceed 10 mg daily. All patients receiving statin therapy should be advised to promptly report any unexplained muscle pain, tenderness or weakness, particularly if accompanied by fever, malaise and/or dark colored urine. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.
References
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tybost (cobicistat)." Gilead Sciences (2014):
- "Product Information. Evotaz (atazanavir-cobicistat)." Bristol-Myers Squibb (2015):
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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